Granzyme A Mouse anti-Mouse, PE, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5831-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15507036

Quantity Price
1 £ 182.82 / 100µg
EU Stock 2
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Regulatory Status RUO
Conjugate PE
Species Reactivity Mouse
Primary or Secondary Primary
Format Conjugated
Isotype IgG2b
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Concentration 0.2mg/mL
Clone GzA-3G8.5
Antigen Granzyme A
Gene Alias CTLA-3, Fragmentin-1, TSP-1

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.