Glial Fibrillary Acid Protein (GFAP) Mouse, eFluor 570, Clone: GA5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 41-9892-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15548986

Quantity Price
1 £ 167.38 / 100µg
EU Stock 1
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Description and Specification

Specification

Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Concentration 0.2mg/mL
Antigen Glial Fibrillary Acid Protein (GFAP)
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Conjugate eFluor 570
Species Reactivity Chicken, Human, Mouse, Pig, Rabbit, Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG1
Clone GA5
Quantity 100μg

This GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, α-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.