Glial Fibrillary Acid Protein (GFAP) Mouse, Alexa Fluor 488, Clone: GA5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-9892-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15352090

Quantity Price
1 £ 174.09 / 100µg
EU Stock 2
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Description and Specification

Specification

Host Species Murine
Clone GA5
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 100μg
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Species Reactivity Chicken, Human, Mouse, Pig, Rabbit, Rat
Primary or Secondary Primary
Antigen Glial Fibrillary Acid Protein (GFAP)
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Alexa Fluor 488

This GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, α-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.