GILZ Rat anti-Mouse, PE, Clone: CFMKG15, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-4033-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15268759

Quantity Price
1 £ 182.82 / 100µg
EU Stock 3
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen GILZ
Format Conjugated
Clone CFMKG15
Host Species Rat
Primary or Secondary Primary
Gene Alias Glucocorticoid-Induced Leucine Zipper, TSC22D3
Applications Flow Cytometry (Intracellular Staining)
Applications Immunocytochemistry
Quantity 100μg
Species Reactivity Mouse
Conjugate PE
Isotype IgG2a
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-κB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-κB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.