Negative control for use in vivo and other experimental settings with high Nuclease activity, BLAST analysis confirms at least 4 mismatches with all known Human, Mouse and Rat genes
siRNA-mediated RNAi experiments should include non-targeting siRNA as a control for non-sequence-specific effects. Changes in mRNA or protein levels in cells treated with these controls reflect a non-specific baseline cellular response to which the levels in cells treated with target-specific siRNA can be compared. Typically, non-targeting controls are siRNAs designed to have comparable GC content to that of the functional siRNA but lack identity with known gene targets.
BLAST analysis confirms at least 4 mismatches with all known human, mouse and rat genes
Chemically modified to significantly extend siRNA stability
Recommended for use as a non-specific control in experiments using siSTABLE modified siRNA against the target gene or where increased stability of the control is desired