GE Healthcare Capto™ Core 700

Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules.

Brand: GE Healthcare

Manufacturer Part Number: 17548102


UNSPSC: 41120000

Code: GE

Additional Details:
Additional Details: Weight: 0.29200kg

Product Code. 12633860

Quantity Price
1 £418.40 / Each
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Description and Specification


Buffer 1M NaOH, 6M Guanidine Hydrochloride, 30% Isopropanol and 70% Ethanol
Product Type Capto Core 700 chromato graphy media
Quantity 100mL
For Use With (Application) Intermediate purification and polishing of viruses and other large biomolecules
Flow Rate <500cm/hr.
Ligand Type Octylamine
pH Range 2 to 14
Particle Size 90μm
Support Type Highly Cross-linked Agarose
Storage Requirements 4° to 30°C

The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin).

  • For intermediate purification and polishing of viruses and other large biomolecules (Mr > 700 000) in flowthrough mode.
  • Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough.
  • Significantly improved productivity and higher flow rates compared with gel filtration methods.
  • Straightforward optimization due to flowthrough chromatography and robust performance.
  • Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns.
  • Capto Core 700 is composed of a ligand-activated core and inactive shell.
  • The inactive shell excludes large molecules (cut off ~ Mr 700000 [700 kDa]) from entering the core through the pores of the shell.
  • These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands.
  • The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core.
  • The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations.
  • Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent.