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GDC 0879, Tocris Bioscience™

Potent B-Raf inhibitor

Brand:  RD Systems (Bio-Techne) 4453/50

Code : Z1

Additional Details : Weight : 0.00050kg

Quantity 50mg

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Product Code. 13464784

  • £779.48 / 50mg


Estimated Shipment
08-01-2019
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Description

Description

Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.
Specifications

Chemical Identifiers

905281-76-7
334.379
e-5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime, 2-4-1-hydroxyimino-2,3-dihydroinden-5-yl-3-pyridin-4-yl pyrazol-1-yl ethanol, 5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime
2-[4-(1-hydroxyimino-2,3-dihydroinden-5-yl)-3-pyridin-4-ylpyrazol-1-yl]ethanol
C19H18N4O2
DEZZLWQELQORIU-UHFFFAOYSA-N
57519545
C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

Specifications

GDC 0879
905281-76-7
e-5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime, 2-4-1-hydroxyimino-2,3-dihydroinden-5-yl-3-pyridin-4-yl pyrazol-1-yl ethanol, 5-1-2-hydroxyethyl-3-pyridin-4-yl-1h-pyrazol-4-yl-2,3-dihydroinden-1-one oxime
C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
334.379
334.37
50mg
C19H18N4O2
DEZZLWQELQORIU-UHFFFAOYSA-N
2-[4-(1-hydroxyimino-2,3-dihydroinden-5-yl)-3-pyridin-4-ylpyrazol-1-yl]ethanol
57519545
>98%
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