Tocris Bioscience™ GBR 12909 dihydrochloride

Selective DA uptake inhibitor; also σ ligand

Description

Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Specifications

• Assay Percent Range: >98%
• Chemical Name or Material: 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
• CAS: 67469-78-7

For Research Use Only