Gata-3 Rat anti-Human, Mouse, Clone: TWAJ, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9966-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258287

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Isotype IgG2b
Species Reactivity Human, Mouse
Monoclonal or Polyclonal Monoclonal
Quantity 25μg
Host Species Rat
Antigen Gata-3
Gene Alias Gata3
Applications Immunocytochemistry
Applications Western Blotting
Primary or Secondary Primary
Concentration 0.5mg/mL
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Clone TWAJ

The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.

Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ Human/Mouse Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein.