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Tocris Bioscience™ Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Brand:  Tocris Bioscience™ 359050

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 13463254

  • £414.72 / 50mg


Estimated Shipment
02-01-2019
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Description

Description

Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤ 100 nM).
Specifications

Specifications

Gambogic acid
Gambogic acid
628.75
50mg
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