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FR4 Rat anti-Mouse, Clone: eBioTH6, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5446-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15238647

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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody eBioTh6 recognizes FR4, also known as FR δ and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and na├»ve T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors.

Based on co-staining studies, the epitopes recognized by eBioTH6 and eBio12A5 (cat 51-5445) are different thereby allowing functional studies with TH6 to be evaluated with eBio12A5.
Specifications

Specifications

FR4
eBioTH6
Unlabeled
Purified
Rat
100μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
1mg/mL
aqueous buffer, no sodium azide
Folate receptor 4, FOLR4 FRdelta, FRd
IgG2b
RUO
Primary
Murine