FR4 Rat anti-Mouse, Clone: eBioTH6, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5446-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238647

Quantity Price
1 £ 201.16 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Gene Alias Folate receptor 4, FOLR4 FRdelta, FRd
Concentration 1mg/mL
Format Purified
Quantity 100μg
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Primary or Secondary Primary
Isotype IgG2b
Storage Requirements Store at 2-8°C.
Clone eBioTH6
Regulatory Status RUO
Host Species Rat
Conjugate Unlabeled
Species Reactivity Mouse
Antigen FR4

The monoclonal antibody eBioTh6 recognizes FR4, also known as FR δ and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naïve T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors.

Based on co-staining studies, the epitopes recognized by eBioTH6 and eBio12A5 (cat 51-5445) are different thereby allowing functional studies with TH6 to be evaluated with eBio12A5.