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FOXP3 Mouse anti-Human, Non-human primate, Rhesus Monkey, eFluor® 570, Clone: 236A/E7, eBioscience™

Mouse Monoclonal Antibody

£130.00 - £301.00

Specifications

Antigen Foxp3
Clone 236A/E7
Target Species Human, Non-human Primate, Rhesus Monkey
Conjugate eFluor™ 570
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15588936 View Documents Affymetrix eBioscience
41-4777-80
25 μg £130.00
25µg View alternative products
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Estimated Shipment date
from Supplier 14-05-2020
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15598936 View Documents Affymetrix eBioscience
41-4777-82
100 μg £301.00
100µg View alternative products
Save Up to 
»
Estimated Shipment date
from Supplier 14-05-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filter Recommendation: When using this eFluor® 570 antibody conjugate, we recommend a filter that will capture the 570 emission wavelength (for example, Excitation 545/25, 565LP, Emission 605/70). A standard Alexa Fluor® 555 or TRITC filter is acceptable. Excitation: 555 nm; Emission: 570 nm FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Specifications

Specifications

Foxp3
Human, Non-human Primate, Rhesus Monkey
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
236A/E7
eFluor™ 570
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.