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Foxp3 Mouse anti-Human, Alexa Fluor 488, Clone: 236A/E7, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-4777-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15580217

  • £92.86 / 25 tests


Estimated Shipment date
from Supplier 28-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 236A/E7 antibody reacts with human Foxp3 protein also known as FORKHEAD BOX P3, SCURFIN, and JM2. Foxp3, a 49-55kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in ‘scurfy’ (sf) mice. Constitutive high expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

Intracellular staining and flow cytometric analysis of freshly isolated human peripheral blood mononuclear cells (PBMCs) with the 236A/E7 antibody using the Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol reveals staining of the CD4+CD25bright population.

The epitope from 236A/E7 is different from that of PCH101 (cat. 72-5776). This antibody has also been shown to recognize rhesus macaque, sooty mangabey and cynomolgus macaque.
Description & Specifications

Specifications

Foxp3
236A/E7
Alexa Fluor 488
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Immunohistochemistry (Frozen)
5μL (0.5μg)/test
Conjugated
Forkhead Box P3, Scurfin, JM2
IgG1
RUO
Primary
Rhesus