FoxA2 Mouse anti-Human, eFluor 660, Clone: 3C10, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-4778-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Disclaimers: For Research Use Only.

Product Code. 15559956

Quantity Price
1 £ 67.82 / 25µg
Estimated Shipment date
from Supplier 02-06-2017
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Description and Specification


Antigen FoxA2
Applications Immunohistochemistry (Formalin/Paraffin)
Clone 3C10
Concentration 0.2mg/mL
Conjugate eFluor 660
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Hepatocyte nuclear factor 3 beta
Host Species Murine
Isotype IgG1
Quantity 25μg
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

This 3C10 monoclonal antibody reacts with human FOXA2, which is also known as hepatocyte nuclear factor 3 beta (HNF3B). This 48kDa member of the Forkhead family of transcription factors is expressed in the liver, pancreas (islets and some acinar cells), lung, and intestine. During development, FOXA2 is necessary for lung bud and pancreatic beta cell formation. Recently, directed expression of FOXA2 in embryonic stem cells has been found to regulate the generation and differentiation of midbrain dopaminergic neurons. It has also been shown to regulate genes involved hepatic lipid metabolism, including alpha fetoprotein, albumin, and transthyretin, as well as Pdx1 in the pancreas. FOXA2 expression is negatively regulated by insulin and reports demonstrate a role for it in sporadic cases of maturity-onset diabetes of the young and the epithelial-to-mesenchymal transition in cancer.