missing translation for 'onlineSavingsMsg'
Learn More

F4/80 Monoclonal Antibody (BM8), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£231.00 - £369.00

Specifications

Antigen F4/80
Clone BM8
Concentration 1 mg/mL
Applications Control, Flow Cytometry, Functional Assay
Classification Monoclonal
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15268627
View Documents Promotion Details
Affymetrix eBioscience
16-4801-85
500 μg
£231.00
500µg
View alternative products
Save Up to 
»
Estimated Shipment: 25-04-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
15278627
View Documents Promotion Details
Affymetrix eBioscience
16-4801-86
1 mg
£369.00
1mg
View alternative products
Save Up to 
»
Estimated Shipment: 25-04-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

EGF-Like Module Containing Mucin-Like Hormone Receptor-Like Sequence 1 (EMR1) is characterized as an Orphan-B GPCR with an unknown ligand. The C-terminus contains seven hydrophobic segments, characteristic of a G protein-coupled receptor. The N-terminus of EMR1 has 6 EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. EMR1 has been reported to be expressed in human peripheral blood mononuclear cells, monocytes, and hematopoietic and solid tumor-derived cell lines. ESTs have been isolated from human normal spleen and mixed liver/spleen libraries and from human kidney, colon, brain, and bone marrow cancer libraries.

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.
Specifications

Specifications

F4/80
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
ADGRE1; Adhesion G protein-coupled receptor E1; Adhesion G protein-coupled receptor E2; cell surface glycoprotein EMR1; cell surface glycoprotein F4/80; DD7A5-7; EGF-like module containing, mucin-like, hormone receptor-like 1; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGF-TM7; Emr1; EMR1 hormone receptor; F4/80; Gpf480; Ly71; lymphocyte antigen 71; TM7LN3
ADGRE1
Primary
4° C
ADGRE1
BM8
Control, Flow Cytometry, Functional Assay
Functional Grade
Rat
Mouse
Q61549
13733
IgG2a κ
Affinity chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.