F4/80 Antigen Rat anti-Mouse, Clone: BM8, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-4801-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268627

Quantity Price
1 £ 182.82 / 500µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Concentration 1mg/mL
Clone BM8
Format Purified
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Isotype IgG2a
Species Reactivity Mouse
Gene Alias Pan Macrophage Marker
Formulation aqueous buffer, no sodium azide
Antigen F4/80 Antigen
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Quantity 500μg
Primary or Secondary Primary
Host Species Rat

The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 125kDa transmembrane protein. The F4/80 antigen is expressed by a majority of mature macrophages and is the best marker for this population of cells. However, other cell types such as Langerhans cells and liver Kupffer cells have been reported to express this antigen. Expression of F4/80 commences during early myeloid development and is upregulated on all BM cells stimulated in vitro with M-CSF. It has been shown that some cytokines downregulate the expression of F4/80 resulting in lack of F4/80 antigen on a subpopulation of macrophages, especially in the lymphoid microenvironment in vivo.