F4/80 Antigen Rat anti-Mouse, Clone: BM8, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-4801-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15287387

Quantity Price
1 £ 91.11 / 100µg
EU Stock 22
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Description and Specification

Specification

Applications Flow Cytometry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Conjugate Unlabeled
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Monoclonal or Polyclonal Monoclonal
Format Purified
Concentration 0.5mg/mL
Regulatory Status RUO
Antigen F4/80 Antigen
Storage Requirements Store at 2-8°C.
Gene Alias EMR1, Ly71, Pan Macrophage Marker
Species Reactivity Mouse
Clone BM8
Isotype IgG2a
Primary or Secondary Primary

The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.