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EZH2 Mouse, Clone: AC22, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9867-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597696

  • £186.31 / 100µg


Estimated Shipment date
from Supplier 28-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody AC22 recognizes EZH2 (Enhancer of zeste homolog 2), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure. EZH2 comprises the catalytic subunit of the polycomb repressive complex 2 (PRC2) and directly represses gene expression through methylation of histone H3 on lysine 27 (H3K27) as well as direct protein targets such as GATA4. The PRC2 complex gene repression is necessary for proper development and differentiation. Underexpression of EZH2 is linked to abnormal developmental patterning and a loss of stem cell pluripotency, while overexpression of EZH2 is present in many tumors and correlates with poor prognosis in melanoma, breast, and prostate cancer.
Description & Specifications

Specifications

EZH2
AC22
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
Purified
Enhancer Of Zeste Homolog 2 (Drosophila)
IgG2a
RUO
Primary
Rat