EZH2 Mouse, Clone: AC22, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9867-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Disclaimers: For Research Use Only.

Product Code. 15597696

Quantity Price
1 £ 186.31 / 100µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification


Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Species Reactivity Human, Mouse, Rat
Isotype IgG2a
Format Purified
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Antigen EZH2
Monoclonal or Polyclonal Monoclonal
Clone AC22
Gene Alias Enhancer Of Zeste Homolog 2 (Drosophila)
Quantity 100μg
Host Species Mouse
Storage Requirements Store at 2-8°C.
Regulatory Status RUO

The monoclonal antibody AC22 recognizes EZH2 (Enhancer of zeste homolog 2), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure. EZH2 comprises the catalytic subunit of the polycomb repressive complex 2 (PRC2) and directly represses gene expression through methylation of histone H3 on lysine 27 (H3K27) as well as direct protein targets such as GATA4. The PRC2 complex gene repression is necessary for proper development and differentiation. Underexpression of EZH2 is linked to abnormal developmental patterning and a loss of stem cell pluripotency, while overexpression of EZH2 is present in many tumors and correlates with poor prognosis in melanoma, breast, and prostate cancer.