Estrogen Receptor alpha Mouse anti-Human, Clone: tbykt, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9740-82

100UG Anti-Human Estrogen Receptor alpha Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577616

Quantity Price
1 £ 241.3 / 100µg
Estimated Shipment date
from Supplier 08-12-2016
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Description and Specification

Specification

Antigen Estrogen Receptor alpha
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Clone tbykt
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias ERa
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The tbykt monoclonal antibody reacts with the human Estrogen Receptor alpha (ERa) molecule. Estrogen receptor is a member of the superfamily of nuclear receptors, which are ligand-dependent transcription factors. The human estrogen receptor becomes activated following the binding of estrogen, causing a dissociation of the chaperone protein (Hsp90) and dimerization with either ERa or ERb. The alpha and beta receptors share some homology within their DNA- and ligand- binding domains, but signal in different ways and play different roles in gene regulation. Following activation, Era can directly bind to DNA through EREs (estrogen response elements) or through a more indirect pathway by binding to other transcription factors (Sp1, AP-1, NF-kB, FoxA1 and others). Era binding to DNA can either upregulate or repress gene expression. The alpha receptor has been implicated in the development and progression of breast cancer and its presence is indicative of improved survival and a better response to endocrine therapy (anti-estrogen therapy- tamoxifen).