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Estrogen Receptor alpha Mouse anti-Human, Clone: tbykt, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9740-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577616

  • £161.27 / 100µg


EU Stock 1
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Disclaimers:

For Research Use Only.


Specifications

Description

The tbykt monoclonal antibody reacts with the human Estrogen Receptor alpha (ERa) molecule. Estrogen receptor is a member of the superfamily of nuclear receptors, which are ligand-dependent transcription factors. The human estrogen receptor becomes activated following the binding of estrogen, causing a dissociation of the chaperone protein (Hsp90) and dimerization with either ERa or ERb. The alpha and beta receptors share some homology within their DNA- and ligand- binding domains, but signal in different ways and play different roles in gene regulation. Following activation, Era can directly bind to DNA through EREs (estrogen response elements) or through a more indirect pathway by binding to other transcription factors (Sp1, AP-1, NF-kB, FoxA1 and others). Era binding to DNA can either upregulate or repress gene expression. The alpha receptor has been implicated in the development and progression of breast cancer and its presence is indicative of improved survival and a better response to endocrine therapy (anti-estrogen therapy- tamoxifen).
Description & Specifications

Specifications

Estrogen Receptor alpha
tbykt
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ERa
IgG1
RUO
Primary
Human