ERK 1/2 Mouse, Clone: 5AD13MA, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9108-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15547576

Quantity Price
1 £ 161.27 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Gene Alias MAPK, ERK, p42/p44
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Quantity 100μg
Monoclonal or Polyclonal Monoclonal
Format Purified
Primary or Secondary Primary
Concentration 0.5mg/mL
Antigen ERK 1/2
Clone 5AD13MA
Host Species Mouse
Isotype IgG1
Regulatory Status RUO
Species Reactivity Human, Mouse, Rat
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.

The 5AD13MA monoclonal antibody recognizes human, mouse, and rat extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1). ERK1/2 belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility, and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK including U0126 and PD98059. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.