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ERK 1/2 Mouse, Clone: 5AD13MA, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9108-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537576

  • £67.82 / 25µg


Estimated Shipment date
from Supplier 26-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The 5AD13MA monoclonal antibody recognizes human, mouse, and rat extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1). ERK1/2 belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility, and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK including U0126 and PD98059. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.
Specifications

Specifications

ERK 1/2
5AD13MA
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
MAPK, ERK, p42/p44
IgG1
RUO
Primary
Rat