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ErbB4 (Her4), Biotin, clone: HFR1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-9687-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547366

  • £160.22 / 100µg


Estimated Shipment date
from Supplier 02-07-2018
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Description

Description

Description: The monoclonal antibody HFR1 recognizes human and mouse epidermal growth factor receptor 4 (ErbB4 or HER4). ErbB4 belongs to the family of receptor tyrosine kinases (RTK) of which HER1 (EGRF), HER2 (ErbB2), and HER3 (ErbB3) are members. RTKs function to affect a variety of cell processes including proliferation, differentiation, migration, survival and apoptosis and are often disregulated in cancer. The ErbB4 protein contains extracellular ligand binding domains, a transmembrane region, and a cytoplasmic tail containing the tyrosine kinase domain and the binding site for the HFR1 antibody. Upon ligand binding, ErbB4 homo- or hetero-dimerizes with other family members, becomes phosphorylated, and can be cleaved allowing translocation to the nucleus. The HRF1 antibody recognizes membrane-bound, cytoplasmic and nuclear ErbB4. Cytosolic ErbB4 expression was found to correlate with a positive prognosis in a subset of breast cancer patients, while nuclear ErbB4 expression was inversely correlated with tumor grade and aggressiveness of breast tumors.Applications Reported: This HFR1 antibody has been reported for use in immunoprecipitation, western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.Applications Tested: This HFR1 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using low pH antigen retrieval at less than or equal to 20 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

erbB4
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q61527, Q15303
c-erbB4
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurine
ImmunocytochemistryþImmunohistochemistryþImmunoprecipitationþWestern Blot
HFR1
Biotin
ERBB4
Conjugated
Erbb4
IgG2b, kappa
100μg
Store at 2-8°C. Do not freeze.
Primary
2066
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