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erbB4 Mouse anti-Human, Mouse, Biotin, Clone: HFR1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-9687-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15537366

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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody HFR1 recognizes human and mouse epidermal growth factor receptor 4 (ErbB4 or HER4). ErbB4 belongs to the family of receptor tyrosine kinases (RTK) of which HER1 (EGRF), HER2 (ErbB2), and HER3 (ErbB3) are members. RTKs function to affect a variety of cell processes including proliferation, differentiation, migration, survival and apoptosis and are often disregulated in cancer. The ErbB4 protein contains extracellular ligand binding domains, a transmembrane region, and a cytoplasmic tail containing the tyrosine kinase domain and the binding site for the HFR1 antibody. Upon ligand binding, ErbB4 homo- or hetero-dimerizes with other family members, becomes phosphorylated, and can be cleaved allowing translocation to the nucleus. The HRF1 antibody recognizes membrane-bound, cytoplasmic and nuclear ErbB4. Cytosolic ErbB4 expression was found to correlate with a positive prognosis in a subset of breast cancer patients, while nuclear ErbB4 expression was inversely correlated with tumor grade and aggressiveness of breast tumors.
Specifications

Specifications

erbB4
HFR1
Biotin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
c-erbB4
IgG2b
RUO
Primary
Murine