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Epidermal Growth Factor Receptor-2 (ErbB2/HER-2) Mouse anti-Human, eFluor 570, Clone: MJD2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 41-9757-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15568956

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance

Disclaimers:

For Research Use Only.


Specifications

Description

This MJD2 monoclonal antibody reacts with HER-2, the product of the ErbB2 gene and a member of the human epidermal growth factor receptor (EGFR) family. HER-2 is a 185kDa transmembrane receptor with an extracellular binding domain and an intracellular tyrosine kinase domain. Activation of HER-2 occurs following formation of homodimers or heterodimers with ligand-bound EGFR family members, HER3 or HER4. Overexpression of HER-2 results in auto-phosphorylation and increased proliferation and invasiveness and is associated with subsets of multiple cancer types such as breast, ovarian, cervical, uterine, and gastric. The use of HER-2 targeted agents has been used extensively to treat HER-2-positive breast cancer, but a recent study found that these agents can also block the proliferation of breast cancer stem cells found in HER-2-negative patients and suggests the importance of HER-2 as a target for multiple types of breast cancer. The MJD2 antibody recognizes the extracellular domain of HER-2 but at an epitope distinct from that recognized by the 4D5 (Herceptin) and SP3 monoclonal antibodies.
Description & Specifications

Specifications

Epidermal Growth Factor Receptor-2 (ErbB2/HER-2)
MJD2
eFluor 570
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Microscopy
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
HER2
IgG1
RUO
Primary
Human