Epidermal Growth Factor Receptor-2 (ErbB2/HER-2) Mouse anti-Human, eFluor 570, Clone: MJD2, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 41-9757-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionThis MJD2 monoclonal antibody reacts with HER-2, the product of the ErbB2 gene and a member of the human epidermal growth factor receptor (EGFR) family. HER-2 is a 185kDa transmembrane receptor with an extracellular binding domain and an intracellular tyrosine kinase domain. Activation of HER-2 occurs following formation of homodimers or heterodimers with ligand-bound EGFR family members, HER3 or HER4. Overexpression of HER-2 results in auto-phosphorylation and increased proliferation and invasiveness and is associated with subsets of multiple cancer types such as breast, ovarian, cervical, uterine, and gastric. The use of HER-2 targeted agents has been used extensively to treat HER-2-positive breast cancer, but a recent study found that these agents can also block the proliferation of breast cancer stem cells found in HER-2-negative patients and suggests the importance of HER-2 as a target for multiple types of breast cancer. The MJD2 antibody recognizes the extracellular domain of HER-2 but at an epitope distinct from that recognized by the 4D5 (Herceptin) and SP3 monoclonal antibodies.
|Epidermal Growth Factor Receptor-2 (ErbB2/HER-2)|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|Immunocytochemistry, Immunohistochemistry, Microscopy|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
For Research Use Only.