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Epidermal Growth Factor Receptor-2 (ErbB2/HER-2) Mouse anti-Human, Clone: MJD2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9757-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597636

  • £167.38 / 100µg


Estimated Shipment date
from Supplier 28-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

This MJD2 monoclonal antibody reacts with HER-2, the product of the ErbB2 gene and a member of the human epidermal growth factor receptor (EGFR) family. HER-2 is a 185kDa transmembrane receptor with an extracellular binding domain and an intracellular tyrosine kinase domain. Activation of HER-2 occurs following formation of homodimers or heterodimers with ligand-bound EGFR family members, HER3 or HER4. Overexpression of HER-2 results in auto-phosphorylation and increased proliferation and invasiveness and is associated with subsets of multiple cancer types such as breast, ovarian, cervical, uterine, and gastric. The use of HER-2 targeted agents has been used extensively to treat HER-2-positive breast cancer, but a recent study found that these agents can also block the proliferation of breast cancer stem cells found in HER-2-negative patients and suggests the importance of HER-2 as a target for multiple types of breast cancer. The MJD2 antibody recognizes the extracellular domain of HER-2 but at an epitope distinct from that recognized by the 4D5 (Herceptin) and SP3 monoclonal antibodies.
Specifications

Specifications

Epidermal Growth Factor Receptor-2 (ErbB2/HER-2)
MJD2
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
HER2
IgG1
RUO
Primary
Human