EphB1 (ephrin B1) Rat anti-Mouse, Clone: 25H11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5300-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15277407

Quantity Price
1 £ 136.24 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Concentration 0.5mg/mL
Format Purified
Antigen EphB1 (ephrin B1)
Primary or Secondary Primary
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Host Species Rat
Isotype IgG2a
Quantity 100μg
Clone 25H11
Gene Alias EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, LERK 2
Storage Requirements Store at 2-8°C.
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody 25H11 recognizes mouse Ephrin B1, a 47kDa membrane protein. Ephrin B1 belongs to a family of ephrins composed of type A (linked to the cell membrane through a glycosylphosphatidyl inositol group) or type B (transmembrane) proteins. The type B ephrins consist of 3 members (B1, B2, and B3) each of which contains a cytoplasmic domain containing tyrosine residues that can be phosphorylated. Ephrin B and ephrin B receptors (Eph B) can interact to potentiate bidirectional downstream signaling between cells expressing either or both the ligand and receptor. Ephrins have been shown to play a role in neural crest cell development through both neurogenesis and neural migration, as well as development of kidney and heart cyto-architecture. Overexpression of type B ephrins in cancer cells is associated with increased vascularity and highly invasive tumors.