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Tocris Bioscience™ Embelin

Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor

Brand:  Tocris Bioscience™ 215610

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 13440684

  • £124.20 / 10mg

Estimated Shipment
08-07-2019

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Description

Description

Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.
Specifications

Specifications

Embelin
>99
10mg
Embelin
294.39
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