EGFR Mouse anti-Human, eFluor 660, Clone: me1B3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9509-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15510107

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Primary or Secondary Primary
Format Conjugated
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate eFluor 660
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25 tests
Monoclonal or Polyclonal Monoclonal
Clone me1B3
Concentration 5μL (0.125μg)/test
Host Species Mouse
Gene Alias ErbB1, Her1
Antigen EGFR
Isotype IgG1
Applications Flow Cytometry

This me1B3 monoclonal antibody reacts with human epidermal growth factor receptor (EGFR), also known as ErbB1 and Her1. EGFR is a receptor tyrosine kinase belonging to the EGFR/ErbB receptor subfamily, which also includes ErbB2/Her2/neu. EGFR contains an extracellular ligand-binding domain, a single transmembrane-spanning region, and a cytoplasmic tail containing a tyrosine kinase domain. Specific ligands include EGF and TNF alpha, as well as other members of the EGF protein family. Upon ligand binding, EGFR undergoes receptor-mediated dimerization with itself or ErbB2/Her2/neu. Dimerization induces auto-phosphorylation, resulting in the activation of PLC gamma, JAK/STAT, MAPK/ERK, and PI3K/AKT signaling pathways. EGFR has a role in cell proliferation, migration and differentiation, and is evolutionarily highly conserved in structure and function. EGFR is broadly expressed and is overexpressed or mutated in glioblastomas and a number of different epithelial cancers, including non-small cell lung cancer and colorectal cancer.