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EGFR Mouse anti-Human, eFluor 660, Clone: me1B3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9509-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15520107

  • £182.82 / 100 tests


EU Stock 1
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Disclaimers:

For Research Use Only.


Description

Description

This me1B3 monoclonal antibody reacts with human epidermal growth factor receptor (EGFR), also known as ErbB1 and Her1. EGFR is a receptor tyrosine kinase belonging to the EGFR/ErbB receptor subfamily, which also includes ErbB2/Her2/neu. EGFR contains an extracellular ligand-binding domain, a single transmembrane-spanning region, and a cytoplasmic tail containing a tyrosine kinase domain. Specific ligands include EGF and TNF alpha, as well as other members of the EGF protein family. Upon ligand binding, EGFR undergoes receptor-mediated dimerization with itself or ErbB2/Her2/neu. Dimerization induces auto-phosphorylation, resulting in the activation of PLC gamma, JAK/STAT, MAPK/ERK, and PI3K/AKT signaling pathways. EGFR has a role in cell proliferation, migration and differentiation, and is evolutionarily highly conserved in structure and function. EGFR is broadly expressed and is overexpressed or mutated in glioblastomas and a number of different epithelial cancers, including non-small cell lung cancer and colorectal cancer.
Specifications

Specifications

EGFR
me1B3
eFluor 660
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ErbB1, Her1
IgG1
RUO
Primary
Human