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EEA1, clone: 1G11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9114-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577576

  • £63.55 / 25µg


EU Stock 1
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Description

Description

Description: The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. EEA1 interacts with Rab5-GTP, syntaxin 6 and syntaxin 13 (SNARES). EEA1 is required for endocytic membrane docking and fusion, which allows for the recycling of receptors from the plasma membrane or their delivery to lysosomes for degradation. In neurons, early endosomes are involved in the recycling of neurotransmitter receptors. Autoantibodies to EEA1 have been found in patients with neurological deficits which result in enhanced excitatory synaptic transmission.Applications Reported: This 1G11 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, ELISA, and immunocytochemistry.Applications Tested: This 1G11 antibody has been tested by immunocytochemistry of fixed and permeabilized HeLa cells and can be used at less than or equal to 1 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Early Endosome Antigen 1 (EEA1)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q15075, Q8BL66
EEA1, Endosome-associated protein p162, Zinc finger FYVE domain-containing protein 2
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Rat
Western Blot
1G11
Unconjugated
EEA1
Purified
EEA1
IgG1, kappa
25μg
Store at 2-8°C.
Primary
8411
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