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Early Endosome Antigen 1 (EEA1) Mouse, Clone: 1G11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9114-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577576

  • £61.70 / 25µg


Estimated Shipment date
from Supplier 03-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. EEA1 interacts with Rab5-GTP, syntaxin 6 and syntaxin 13 (SNARES). EEA1 is required for endocytic membrane docking and fusion, which allows for the recycling of receptors from the plasma membrane or their delivery to lysosomes for degradation. In neurons, early endosomes are involved in the recycling of neurotransmitter receptors. Autoantibodies to EEA1 have been found in patients with neurological deficits which result in enhanced excitatory synaptic transmission.
Description & Specifications

Specifications

Early Endosome Antigen 1 (EEA1)
1G11
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Rat
Western Blot
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal