Early Endosome Antigen 1 (EEA1) Mouse, Clone: 1G11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9114-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577576

Quantity Price
1 £ 61.7 / 25µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Format Purified
Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Primary or Secondary Primary
Isotype IgG1
Clone 1G11
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human, Mouse, Rat
Host Species Mouse
Antigen Early Endosome Antigen 1 (EEA1)
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Quantity 25μg

The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. EEA1 interacts with Rab5-GTP, syntaxin 6 and syntaxin 13 (SNARES). EEA1 is required for endocytic membrane docking and fusion, which allows for the recycling of receptors from the plasma membrane or their delivery to lysosomes for degradation. In neurons, early endosomes are involved in the recycling of neurotransmitter receptors. Autoantibodies to EEA1 have been found in patients with neurological deficits which result in enhanced excitatory synaptic transmission.