Thermo Scientific™ DyLight™ In Vivo Apoptosis Detection Kits and Reagents

Measure drug-induced changes in apoptosis in vivo (live animal imaging) using near-infrared DyLight Dye fluorescent polycaspase probes.

Brand: Thermo Scientific™

Manufacturer Part Number: 84897

UNSPSC: 12352200

Code: PN

Additional Details:
Additional Details: Weight: 0.01000kg

Product Code. 12112400

Quantity Price
1 £ 49.0 / 5mL
Estimated Shipment date
from Supplier 12-05-2017
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Description and Specification


Formulation Proprietary in vivo caspase probe injection buffer
Sufficient For Preparing 50mL of 1X Injection Buffer
Description 10X Injection Buffer
Quantity 5mL

These kits contain a DyLight 690- or DyLight 747-conjugated in vivo polycaspase probe, which is a cell-permeable fluorescent detector of active caspases indicative of apoptosis. The probes are comprised of a polycaspase peptide sequence (VAD) and a fluoromethyl ketone (FMK) moiety, which facilitate irreversible binding of the probe to active caspases, and either DyLight 690 or DyLight 747 Dye for near-infrared detection with a range of in vivo instrumentation. These probes are valuable for in vivo drug determination studies, because changes in apoptosis from drug reactivity can be measured by fluorescence imaging in live animals. An increase in apoptosis produces a greater attachment of probes and, subsequently, an increase in fluorescence output. The in vivo technique is nondestructive, thus eliminating the need to remove cells and tissues from sacrificed animals prior to analysis (which induces further apoptosis). Additionally, apoptosis can be monitored in a single animal at multiple time points, reducing the number of animals required for a given study.


  • Nontoxic–not harmful to valuable research animals

  • Cell-permeable–readily diffuses through all cells as it circulates throughout the body

  • Selective for active caspases–eliminates high background and false-positive results common with other caspase detection methods

Recommended for:

Small-animal in vivo apoptosis imaging