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DR3 Mouse anti-Human, PE, Clone: JD3, eBioscience™

Mouse Monoclonal Antibody

£79.25 - £185.00

Specifications

Antigen DR3
Clone JD3
Target Species Human
Conjugate PE
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15587066
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Affymetrix eBioscience
12-6603-41
25 Tests £79.25
25 tests View alternative products
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Estimated Shipment
30-11-2020
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15597066
View Documents
Affymetrix eBioscience
12-6603-42
100 Tests £185.00
100 tests View alternative products
Save Up to 
»
Estimated Shipment
30-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predomitly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Specifications

Specifications

DR3
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
JD3
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.