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Dorsomorphin dihydrochloride, Tocris Bioscience™

Potent AMPK inhibitor

Brand:  Tocris (Bio-Techne) 309350

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13442384

  • £740.88 / 50mg

Estimated Shipment date
from Supplier 28-10-2019

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Description

Description

Potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and metformin (Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
Specifications

Chemical Identifiers

1219168-18-9
472.414
dorsomorphin dihydrochloride, dorsomorphin 2hcl, compound c, 4-6-4-2-piperidin-1-yl ethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl pyridine dihydrochloride, 6-4-2-1-piperidinyl ethoxy phenyl-3-4-pyridinyl-pyrazolo 1,5-a pyrimidine dihydrochloride, 6-4-2-piperidin-1-ylethoxy phenyl-3-pyridin-4-ylpyrazolo 1,5-a pyrimidine;dihydrochloride, 6-4-2-piperidin-1-yl ethoxy phenyl-3-pyridin-4-yl pyrazolo 1,5-a pyrimidine dihydrochloride, dorsomorphin dihydrochlorid, dorsomorphin compound c 2hcl
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
C24H27Cl2N5O
RJDVIJJQKMGPMV-UHFFFAOYSA-N
49761481
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Specifications

50mg
1219168-18-9
dorsomorphin dihydrochloride, dorsomorphin 2hcl, compound c, 4-6-4-2-piperidin-1-yl ethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl pyridine dihydrochloride, 6-4-2-1-piperidinyl ethoxy phenyl-3-4-pyridinyl-pyrazolo 1,5-a pyrimidine dihydrochloride, 6-4-2-piperidin-1-ylethoxy phenyl-3-pyridin-4-ylpyrazolo 1,5-a pyrimidine;dihydrochloride, 6-4-2-piperidin-1-yl ethoxy phenyl-3-pyridin-4-yl pyrazolo 1,5-a pyrimidine dihydrochloride, dorsomorphin dihydrochlorid, dorsomorphin compound c 2hcl
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
472.414
472.41
Dorsomorphin dihydrochloride
C24H27Cl2N5O
RJDVIJJQKMGPMV-UHFFFAOYSA-N
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride
49761481
>98%
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