DLL1 (delta-like 1) Armenian Hamster anti-Mouse, Alexa Fluor 488, Clone: HMD1-5, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-5767-80

25UG ANTI-MOUSE DLL1 (DELTA-LIKE 1) AF 488

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15342040

Quantity Price
1 £ 107.0 / 25µg
Estimated Shipment date
from Supplier 07-12-2016
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Description and Specification

Specification

Antigen DLL1 (delta-like 1)
Applications Flow Cytometry
Clone HMD1-5
Concentration 0.5mg/mL
Conjugate Alexa Fluor 488
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias DL1
Host Species Armenian Hamster
Isotype IgG
Quantity 25μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis.