DLL1 (delta-like 1) Armenian Hamster anti-Mouse, Alexa Fluor 488, Clone: HMD1-5, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-5767-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15352040

Quantity Price
1 £ 188.93 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Isotype IgG
Primary or Secondary Primary
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Applications Flow Cytometry
Clone HMD1-5
Antigen DLL1 (delta-like 1)
Regulatory Status RUO
Host Species Armenian Hamster
Quantity 100μg
Monoclonal or Polyclonal Monoclonal
Gene Alias DL1
Concentration 0.5mg/mL
Conjugate Alexa Fluor 488
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis.