Disialoganglioside GD3 Mouse anti-Human, Clone: MB3.6, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9754-82
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionThe monoclonal antibody MB3.6 recognizes human disialoganglioside GD3, a membrane-bound sialic acid-containing glycosphingolipid. Gangliosides are synthesized in the Golgi apparatus by glycosyltransferases before localizing to the plasma membrane. Gangliosides function as receptors for growth factors and hormones as well as mediating interaction with adhesion molecules at the surface of all cells. GD3 is expressed at low levels in retina pigment cells and melanocytes. Elevated GD3 levels are found in neural stem cells, epithelial-origin tumor cells (cervical, ovarian, prostate, breast, and skin), as well as T-cell leukemic lymphoblasts (T-ALL). The GD3 monoclonal antibody has been reported to fix complement and induce antibody-dependent cytotoxicity of melanoma cell lines.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C.|