Disialoganglioside GD3 Mouse anti-Human, Clone: MB3.6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9754-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15557636

Quantity Price
1 £ 149.04 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Quantity 100μg
Primary or Secondary Primary
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Antigen Disialoganglioside GD3
Regulatory Status RUO
Isotype IgG3
Concentration 0.5mg/mL
Host Species Mouse
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.
Format Purified
Clone MB3.6

The monoclonal antibody MB3.6 recognizes human disialoganglioside GD3, a membrane-bound sialic acid-containing glycosphingolipid. Gangliosides are synthesized in the Golgi apparatus by glycosyltransferases before localizing to the plasma membrane. Gangliosides function as receptors for growth factors and hormones as well as mediating interaction with adhesion molecules at the surface of all cells. GD3 is expressed at low levels in retina pigment cells and melanocytes. Elevated GD3 levels are found in neural stem cells, epithelial-origin tumor cells (cervical, ovarian, prostate, breast, and skin), as well as T-cell leukemic lymphoblasts (T-ALL). The GD3 monoclonal antibody has been reported to fix complement and induce antibody-dependent cytotoxicity of melanoma cell lines.