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Desmin Mouse, Clone: DE-U-10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9747-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547626

  • £67.82 / 25µg


Estimated Shipment date
from Supplier 30-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody DE-U-10 recognizes desmin. Desmin is the protein subunit of class-III intermediate filaments. Desmin is found predominantly in skeletal, cardiac, and smooth muscle. Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function. Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells. Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function. Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome).

The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin. The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas.
Description & Specifications

Specifications

Desmin
DE-U-10
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Sheep
Western Blot
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal