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Desmin, clone: DE-U-10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9747-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15547626

  • £70.27 / 25µg


Estimated Shipment date
from Supplier 30-05-2018
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Description

Description

Description: The monoclonal antibody DE-U-10 recognizes desmin. Desmin is the protein subunit of class-III intermediate filaments. Desmin is found predominantly in skeletal, cardiac, and smooth muscle. Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function. Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells. Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function. Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome).The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin. The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas.Applications Reported: This DE-U-10 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry.Applications Tested: This DE-U-10 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using either low or high pH antigen retrieval and can be used at less than or equal to 5 μg/mL. This DE-U-10 antibody has been tested by immunocytochemistry of methanol-fixed and permeabilized mouse cells and can be used at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Desmin
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
O62654, P02542, P17661, P31001, P02540, P48675
CMD1I, CSM2, DES, FLJ12025
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Sheep
Western Blot
DE-U-10
Unconjugated
DES
Purified
DES
IgG1, kappa
25μg
Store at 2-8°C.
Primary
1674
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