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Delta-like 4 Functional Grade Armenian Hamster anti-Mouse, Clone: HMD4-1, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5948-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258707

  • £170.59 / 100µg


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For Research Use Only.


Description

Description

This HMD4-1 monoclonal antibody reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature.

The HMD4-1 monoclonal antibody has been reported to have blocking activity and crossreact to rat.
Specifications

Specifications

Delta-like 4 Functional Grade
HMD4-1
Unconjugated
Purified
Armenian Hamster
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
DLL4
IgG
RUO
Primary
Rat
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