Delta-like 4 Functional Grade Armenian Hamster anti-Mouse, Clone: HMD4-1, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5948-82


UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15248707

Quantity Price
1 £ 107.0 / 100µg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification


Antigen Delta-like 4 Functional Grade
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias DLL4
Applications Functional Assay
Isotype IgG
Quantity 100μg
Regulatory Status RUO
Species Reactivity Mouse, Rat
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Clone HMD4-1
Concentration 1mg/mL
Conjugate Unlabeled
Host Species Armenian Hamster
Monoclonal or Polyclonal Monoclonal

This HMD4-1 monoclonal antibody reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature.

The HMD4-1 monoclonal antibody has been reported to have blocking activity and crossreact to rat.