Delta-like 4 Functional Grade Armenian Hamster anti-Mouse, Clone: HMD4-1, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5948-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248707

Quantity Price
1 £ 78.88 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Species Reactivity Mouse, Rat
Applications Functional Assay
Primary or Secondary Primary
Clone HMD4-1
Conjugate Unlabeled
Quantity 100μg
Isotype IgG
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Concentration 1mg/mL
Formulation aqueous buffer, no sodium azide
Antigen Delta-like 4 Functional Grade
Gene Alias DLL4
Format Purified
Monoclonal or Polyclonal Monoclonal
Host Species Armenian Hamster

This HMD4-1 monoclonal antibody reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature.

The HMD4-1 monoclonal antibody has been reported to have blocking activity and crossreact to rat.