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DCPIB, Tocris Bioscience™

Selective blocker of VSAC/ICl, swell

Brand:  Tocris (Bio-Techne) 154050

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13459633

  • £500.52 / 50mg


Estimated Shipment
31-08-2018
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Description

Description

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ∽ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.
Specifications

Chemical Identifiers

82749-70-0
427.362
4-[(2-Butyl-6, 7-dichloro-2-cyclopentyl-2, 3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
C22H28Cl2O4
KHKGTPJPBOQECW-UHFFFAOYSA-N
10071166

Specifications

DCPIB
>98%
C22H28Cl2O4
KHKGTPJPBOQECW-UHFFFAOYSA-N
4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid
10071166
82749-70-0
50mg
4-[(2-Butyl-6, 7-dichloro-2-cyclopentyl-2, 3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCCCC(=O)O)C3CCCC3
427.362
427.37
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