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DAPT, Tocris Bioscience™

γ-secretase inhibitor

Brand:  Tocris (Bio-Techne) 263450

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13461614

  • £719.00 / 50mg


Estimated Shipment
31-08-2018
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Description

Description

Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes ESCs to commit to neuronal differentiation.
Specifications

Chemical Identifiers

208255-80-5
432.468
N-[(3, 5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1, 1-dimethylethyl ester
CHEBI:86193
C23H26F2N2O4
DWJXYEABWRJFSP-XOBRGWDASA-N
5311272

Specifications

DAPT
208255-80-5
C23H26F2N2O4
DWJXYEABWRJFSP-XOBRGWDASA-N
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
5311272
432.46
50mg
>99%
N-[(3, 5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1, 1-dimethylethyl ester
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
432.468
CHEBI:86193
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