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Cutaneous Lymphocyte Antigen Rat anti-Human, eFluor 660, Clone: HECA-452, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9857-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15500157

  • £140.48 / 100µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Specifications

Description

This HECA-452 monoclonal antibody reacts with human Cutaneous Lymphocyte Antigen (CLA). This cell surface glycoprotein is most highly expressed on T cells in the skin. Nevertheless, CLA can also be detected on some peripheral T and NK cells, as well as monocytes, neutrophils and CD1a+ dendritic cells. Studies have determined that this antibody recognizes sialofucosylated glycans and sialyl Lewis x (sLex). CLA, which binds E-selectin and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), is involved in T lymphocyte infiltration and adhesion at cutaneous sites of inflammation.

The HECA-452 antibody has been reported to inhibit sLex binding to E-selectin; however, this property is still under debate in the literature.
Description & Specifications

Specifications

Cutaneous Lymphocyte Antigen
HECA-452
eFluor 660
Conjugated
IgM
RUO
Primary
Human
Western Blot
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal