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Gibco™ CTS™ Vitronectin (VTN-N) Recombinant Human Protein, Truncated

CTS™ (Cell Therapy Systems) Vitronectin (VTN-N) Recombinant Human Protein provides a defined surface for feeder-free culture of human pluripotent stem cells (PSCs).

Brand:  Gibco™ A27940

Additional Details : Weight : 0.00100kg

Product Code. 15697868

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Description

Description

  • Provides a defined surface for feeder-free culture of human pluripotent stem cells (PSCs)
  • When used with Essential 8™ Medium (Cat. No. A1517001), CTS™ Vitronectin has been proven to maintain pluripotency and normal growth characteristics in multiple PSC lines
  • Shown to support PSC growth for >8 passages without any signs of karyotypic abnormalities and to maintain the ability of PSCs to differentiate into all three germ line lineages
  • VTN-N variant of vitronectin supports human pluripotent stem cell attachment and survival better than wild-type vitronectin when used in conjunction with Essential 8 Medium (1)
  • Designed for clinical research—USP Chapter 1043 considered in the design
  • Animal origin–free—for reduced variability and contamination risk in PSC cultures
  • Optimized—designed for use with Essential 8 Medium
  • Consistent—supports seamless transition from Vitronectin
  • Traceable—documentation includes COO, COA, and DMF
  • Controlled—manufactured in compliance with ISO-13485:2003

Designed for clinical research

  • USP Chapter 1043 has been considered in the design of CTS™ Vitronectin, and this product is the only such product labeled with 'For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products. CAUTION: Not intended for direct administration to humans or animals.'
  • Harmonized documentation is provided with the product and includes a Certificate of Analysis (COA), Certificate of Origin (COO), and Drug Master File (DMF) to support regulatory filings.

Animal origin–free system

  • CTS™ Vitronectin is animal origin–free at the primary level to help reduce contamination risk and variability associated with animal-origin raw materials compared to human plasma–derived vitronectin and standard basement membrane extraCTS™ (BMEs)

Optimized and defined surface

  • Unlike standard basement membrane extraCTS™ (BMEs), CTS™ Vitronectin is based on the N-variant design of vitronectin (VTN-N) from the laboratory of James Thomson for use with Essential 8 Medium (1) and has been shown to support human pluripotent stem cell attachment and survival better than wild type vitronectin
  • Provides an optimal environment for feeder-free pluripotent stem cell culture.

Seamless transition from bench to clinic

  • PSC cultures expanded in other feeder or feeder-free systems can be transitioned to Essential 8 Medium and CTS™ Vitronectin with minimal adaptation

Manufacturing control and traceability

  • CTS™ Vitronectin is manufactured at a site that is FDA registered and has an ISO13485-certified quality management system
  • Full traceability documentation such as Certificate of Origin, Certificate of Analysis, and Drug Master File are available
Specifications

Specifications

1 mL
Recombinant
Animal Origin-Free
Recombinant
Vitronectin
Human
Supplied at a concentration of 0.9 mg/mL.
Store at -80°C and protect from light.
Dry Ice
Liquid
CTS™
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Designed for clinical researchUSP Chapter 1043 has been considered in the design of CTS™ Vitronectin, and this product is the only such product labeled with For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products. CAUTION: Not intended for direct administration to humans or animals. Harmonized documentation is provided with the product and includes a Certificate of Analysis (COA) and Certificate of Origin (COO) to support regulatory filings.