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Connexin 43 Mouse anti-Human, Mouse, Rat, Clone: Connexin43 (1A), eBioscience™

Mouse Monoclonal Antibody

£104.00 - £266.00

Specifications

Antigen Connexin 43
Clone Connexin43 (1A)
Target Species Human, Mouse, Rat
Conjugate Unconjugated
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15567446
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Affymetrix eBioscience
14-4759-80
25 μg £104.00
25µg View alternative products
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Estimated Shipment
30-11-2020
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15577446
View Documents
Affymetrix eBioscience
14-4759-82
100 μg £266.00
100µg View alternative products
Save Up to 
»
Estimated Shipment
30-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.
Specifications

Specifications

Connexin 43
Human, Mouse, Rat
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
Connexin43 (1A)
Unconjugated
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.