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Connexin 43 Mouse anti-Human, Mouse, Rat, Clone: Connexin43 (1A), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-4759-80

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15567446

  • £104.00 / 25µg

Estimated Shipment
04-01-2021

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Beschreibung

Beschreibung

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.
Spezifikation

Spezifikation

Connexin 43
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P08050, P23242, P17302
CX43, DFNB38, GJAL, HSS, ODDD
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Connexin43 (1A)
Unconjugated
GJA1
Liquid
Gja1
IgG1, kappa
25 μg
4° C
Primary
14609, 24392, 2697
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.