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Connexin 43, Biotin, clone: Connexin43 (1A), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-4759-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15567336

  • £63.84 / 25µg


Estimated Shipment date
from Supplier 03-07-2018
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Description

Description

Description: The Connexin43 monoclonal antibody recognizes mouse Connexin 43. Connexins are a family of integral membrane proteins that form gap junction channels, which function to facilitate direct cell-cell communication. Gap junctions are comprised of two hemichannels, or connexons, which are made up of six connexin proteins. Over 20 connexin proteins have been identified and each combine to form either homomeric or heteromeric channels with different functional properties. Connexin 43 is expressed in many tissues, including the central nervous system, heart, and bone. Connexin 43 is the most abundant connexin found in the myocardium and is also the primary connexin expressed in astrocytes. Mutations in connexin 43 are associated with ocluodentodigital dysplasia, a rare developmental disorder characterized by craniofacial and limb abnormalities. Connexin 43 may also be a promising therapeutic target in the treatment of malignant melanomas and mammary gland tumors.The monoclonal antibody Connexin43 also recognizes human and rat connexin 43.Applications Reported: This Connexin43 antibody has been reported for use in immunocytochemistry, and immunohistochemical staining of frozen tissue sections.Applications Tested: This Connexin43 antibody has been tested by immunohistochemistry of frozen mouse tissue and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Connexin 43
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P17302, P23242, P08050
CX43, DFNB38, GJAL, HSS, ODDD
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurineþRat
ImmunocytochemistryþImmunohistochemistry (Frozen)
Connexin43 (1A)
Biotin
GJA1
Conjugated
GJA1
IgG1, kappa
25μg
Store at 2-8°C. Do not freeze.
Primary
2697
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