CMKLR1 Rat anti-Human, Clone: BZ332, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-7581-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218087

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Primary or Secondary Primary
Species Reactivity Human
Applications Flow Cytometry
Conjugate Unlabeled
Isotype IgG2a
Antigen CMKLR1
Clone BZ332
Format Purified
Quantity 25μg
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Gene Alias serpentine chemokine-like receptor 1

The BZ332 antibody reacts with human chemokine-like receptor 1, CMKLR1. CMKLR1 (also known as ChemR23 or DEZ), is a recently-described serpentine chemoattractant receptor. CMKLR1 has been shown to be expressed by dendritic cells (DC) generated in vitro from monocytes, and to mediate their migration to the proteolytically regulated chemoattractant chemerin. CMKLR1 is expressed by circulating DCs in human blood. Importantly, it is selectively expressed by immature plasmacytoid DCs, but not myeloid DCs, thus enabling discrimination between these two dendritic cell lineages. While CMKLR1 is expressed by circulating pDCs in human blood, mDCs, as well as lymphocytes, monocytes, neutrophils, and eosinophils are negative. Human serum contains a chemoattractant for CMKLR1 which is identical with chemerin; this activity is triggered during blood coagulation, suggesting a mechanism for attraction of pDCs to sites of tissue damage and bleeding. Expression of CMKLR1 and migration to locally activated chemerin may allow the rapid and differential recruitment of pDCs in vivo. Unlike mDCs, circulating pDCs do not respond to inflammatory chemokines.