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Clofarabine, Tocris Bioscience™

Deoxycytidine kinase (dCK) substrate

Brand:  Tocris (Bio-Techne) 260050

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13441554

  • £771.75 / 50mg

Estimated Shipment date
from Supplier 20-11-2019

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Description

Description

Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Specifications

Chemical Identifiers

123318-82-1
303.678
clofarabine, clolar, evoltra, clofarex, cafda, clofarabina, clofarabinum, clofarabine usan, cl-f-ara-a, c1-f-ara-a
CHEBI:681569
C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl
C10H11ClFN5O3
WDDPHFBMKLOVOX-AYQXTPAHSA-N
119182
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Specifications

50mg
123318-82-1
clofarabine, clolar, evoltra, clofarex, cafda, clofarabina, clofarabinum, clofarabine usan, cl-f-ara-a, c1-f-ara-a
C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl
303.678
CHEBI:681569
>99%
Clofarabine
C10H11ClFN5O3
WDDPHFBMKLOVOX-AYQXTPAHSA-N
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
119182
303.68
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