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CGP 57380, Tocris Bioscience™

Selective inhibitor of Mnk1

Brand:  RD Systems (Bio-Techne) 27311

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 1mg

 View more versions of this product

Product Code. 13441824

  • £104.37 / 1mg

Estimated Shipment date
from Supplier 20-11-2019

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Description

Description

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.
Specifications

Chemical Identifiers

522629-08-9
244.233
mnk1 inhibitor, n3-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 4-amino-5-4-fluoroanilino-pyrazolo 3,4-d pyrimidine, d0a7fq, cgp hplc, n-4-fluorophenyl-3h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-1h-pyrazolo-3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine
3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
C11H9FN6
UQPMANVRZYYQMD-UHFFFAOYSA-N
11644425
C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F

Specifications

1mg
522629-08-9
mnk1 inhibitor, n3-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 4-amino-5-4-fluoroanilino-pyrazolo 3,4-d pyrimidine, d0a7fq, cgp hplc, n-4-fluorophenyl-3h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-1h-pyrazolo 3,4-d pyrimidine-3,4-diamine, 3-n-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-1h-pyrazolo-3,4-d pyrimidine-3,4-diamine, n3-4-fluorophenyl-2h-pyrazolo 3,4-d pyrimidine-3,4-diamine
C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F
244.233
244.23
CGP 57380
C11H9FN6
UQPMANVRZYYQMD-UHFFFAOYSA-N
3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
11644425
>98%
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