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CGP 57380, Tocris Bioscience™

Selective inhibitor of Mnk1

Brand:  Tocris (Bio-Techne) 273110

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 10mg

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Product Code. 13461824

  • £183.48 / 10mg


Estimated Shipment
02-10-2018
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Description

Description

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages.
Specifications

Chemical Identifiers

522629-08-9
244.233
N3-(4-Fluorophenyl)-1H-pyrazolo-[3, 4-d]pyrimidine-3, 4-diamine
C11H9FN6
UQPMANVRZYYQMD-UHFFFAOYSA-N
11644425

Specifications

CGP 57380
522629-08-9
C11H9FN6
UQPMANVRZYYQMD-UHFFFAOYSA-N
3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
11644425
10mg
>98%
N3-(4-Fluorophenyl)-1H-pyrazolo-[3, 4-d]pyrimidine-3, 4-diamine
C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F
244.233
244.23
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